Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors
Identifieur interne : 000D52 ( Main/Exploration ); précédent : 000D51; suivant : 000D53Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors
Auteurs : Vathan Kumar [Taïwan] ; Jin Soo Shin [Corée du Sud] ; Jiun-Jie Shie [Taïwan] ; Keun Bon Ku [Corée du Sud] ; Chonsaeng Kim [Corée du Sud] ; Yun Young Go [Corée du Sud] ; Kai-Fa Huang [Taïwan] ; Meehyein Kim [Corée du Sud] ; Po-Huang Liang [Taïwan]Source :
- Antiviral Research [ 0166-3542 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (isolement et purification), Antiviraux (pharmacologie), Chats, Coronavirus (), Coronavirus du syndrome respiratoire du Moyen-Orient (), Découverte de médicament, Humains, Infections à coronavirus (virologie), Inhibiteurs de protéases (pharmacologie), Peptidomimétiques (), Peptidomimétiques (pharmacologie), Protéines virales, Virus du SRAS ().
- MESH :
- isolement et purification : Antiviraux.
- pharmacologie : Antiviraux, Inhibiteurs de protéases, Peptidomimétiques.
- virologie : Infections à coronavirus.
- Animaux, Antiviraux, Chats, Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient, Découverte de médicament, Humains, Peptidomimétiques, Protéines virales, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Cats, Coronavirus (drug effects), Coronavirus Infections (virology), Drug Discovery, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Peptidomimetics (chemistry), Peptidomimetics (pharmacology), Protease Inhibitors (pharmacology), SARS Virus (drug effects), Viral Proteins.
- MESH :
- chemical , chemistry : Antiviral Agents, Peptidomimetics.
- chemical , isolation & purification : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents, Peptidomimetics, Protease Inhibitors.
- drug effects : Coronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections.
- Animals, Cats, Drug Discovery, Humans, Viral Proteins.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has resulted in 1826 human infections, including 649 deaths. Analogous to picornavirus 3C protease (3Cpro), 3C-like protease (3CLpro) is critical for initiation of the MERS-CoV replication cycle and is thus regarded as a validated drug target. As presented here, our peptidomimetic inhibitors of enterovirus 3Cpro (
Url:
DOI: 10.1016/j.antiviral.2017.02.007
PubMed: 28216367
PubMed Central: 7113684
Affiliations:
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Le document en format XML
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sort="Shin, Jin Soo" uniqKey="Shin J" first="Jin Soo" last="Shin">Jin Soo Shin</name><affiliation wicri:level="1"><nlm:aff id="aff2">Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korea Research Institute of Chemical Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name><affiliation wicri:level="1"><nlm:aff id="aff3">Institute of Chemistry, Academia Sinica, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Chemistry, Academia Sinica, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Ku, Keun Bon" sort="Ku, Keun Bon" uniqKey="Ku K" first="Keun Bon" last="Ku">Keun Bon Ku</name><affiliation wicri:level="1"><nlm:aff 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Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korea Research Institute of Chemical Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Kai Fa" sort="Huang, Kai Fa" uniqKey="Huang K" first="Kai-Fa" last="Huang">Kai-Fa Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biological Chemistry, Academia Sinica, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Meehyein" sort="Kim, Meehyein" uniqKey="Kim M" first="Meehyein" last="Kim">Meehyein Kim</name><affiliation wicri:level="1"><nlm:aff id="aff2">Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korea Research Institute of Chemical Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biological Chemistry, Academia Sinica, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biochemical Sciences, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Cats</term><term>Coronavirus (drug effects)</term><term>Coronavirus Infections (virology)</term><term>Drug Discovery</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Peptidomimetics (chemistry)</term><term>Peptidomimetics (pharmacology)</term><term>Protease Inhibitors (pharmacology)</term><term>SARS Virus (drug effects)</term><term>Viral Proteins</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Chats</term><term>Coronavirus ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Découverte de médicament</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Inhibiteurs de protéases (pharmacologie)</term><term>Peptidomimétiques ()</term><term>Peptidomimétiques (pharmacologie)</term><term>Protéines virales</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Peptidomimetics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Peptidomimetics</term><term>Protease Inhibitors</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Inhibiteurs de protéases</term><term>Peptidomimétiques</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cats</term><term>Drug Discovery</term><term>Humans</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Chats</term><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Découverte de médicament</term><term>Humains</term><term>Peptidomimétiques</term><term>Protéines virales</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has resulted in 1826 human infections, including 649 deaths. Analogous to picornavirus 3C protease (3C<sup>pro</sup>), 3C-like protease (3CL<sup>pro</sup>) is critical for initiation of the MERS-CoV replication cycle and is thus regarded as a validated drug target. As presented here, our peptidomimetic inhibitors of enterovirus 3C<sup>pro</sup> (<bold>6b</bold>, <bold>6c</bold> and <bold>6d</bold>) inhibited 3CL<sup>pro</sup> of MERS-CoV and severe acute respiratory syndrome coronavirus (SARS-CoV) with IC<sub>50</sub> values ranging from 1.7 to 4.7 μM and from 0.2 to 0.7 μM, respectively. In MERS-CoV-infected cells, the inhibitors showed antiviral activity with EC<sub>50</sub> values ranging from 0.6 to 1.4 μM, by downregulating the viral protein production in cells as well as reducing secretion of infectious viral particles into culture supernatants. They also suppressed other α- and β-CoVs from human and feline origin. These compounds exhibited good selectivity index (over 70 against MERS-CoV) and could lead to the development of broad-spectrum antiviral drugs against emerging CoVs and picornaviruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Akaji, K" uniqKey="Akaji K">K. Akaji</name></author><author><name sortKey="Konno, H" uniqKey="Konno H">H. Konno</name></author><author><name sortKey="Mitsui, H" uniqKey="Mitsui H">H. Mitsui</name></author><author><name sortKey="Teruya, K" uniqKey="Teruya K">K. Teruya</name></author><author><name sortKey="Shimamoto, Y" uniqKey="Shimamoto Y">Y. Shimamoto</name></author><author><name sortKey="Hattori, Y" uniqKey="Hattori Y">Y. Hattori</name></author><author><name sortKey="Ozaki, T" uniqKey="Ozaki T">T. Ozaki</name></author><author><name sortKey="Kusunoki, M" uniqKey="Kusunoki M">M. Kusunoki</name></author><author><name sortKey="Sanjoh, A" uniqKey="Sanjoh A">A. Sanjoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akaji, K" uniqKey="Akaji K">K. Akaji</name></author><author><name sortKey="Konno, H" uniqKey="Konno H">H. Konno</name></author><author><name sortKey="Onozuka, M" uniqKey="Onozuka M">M. Onozuka</name></author><author><name sortKey="Makino, A" uniqKey="Makino A">A. Makino</name></author><author><name sortKey="Saito, H" uniqKey="Saito H">H. Saito</name></author><author><name sortKey="Nosaka, K" uniqKey="Nosaka K">K. Nosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P. Wadhwani</name></author><author><name sortKey="Mesters, J R" uniqKey="Mesters J">J.R. Mesters</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author><author><name sortKey="Kumaki, Y" uniqKey="Kumaki Y">Y. Kumaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Choi, G K" uniqKey="Choi G">G.K. Choi</name></author><author><name sortKey="To, K K" uniqKey="To K">K.K. To</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H. Tse</name></author><author><name sortKey="Cai, J P" uniqKey="Cai J">J.P. Cai</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M.L. Yeung</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Che, X Y" uniqKey="Che X">X.Y. Che</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wilde, A H" uniqKey="De Wilde A">A.H. de Wilde</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Oudshoorn, D" uniqKey="Oudshoorn D">D. Oudshoorn</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Van Nieuwkoop, S" uniqKey="Van Nieuwkoop S">S. van Nieuwkoop</name></author><author><name sortKey="Limpens, R W A L" uniqKey="Limpens R">R.W.A.L. Limpens</name></author><author><name sortKey="Posthuma, C C" uniqKey="Posthuma C">C.C. Posthuma</name></author><author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y. van der Meer</name></author><author><name sortKey="Barcena, M" uniqKey="Barcena M">M. Bárcena</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Van Den Hoogen, B G" uniqKey="Van Den Hoogen B">B.G. van den Hoogen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dyall, J" uniqKey="Dyall J">J. Dyall</name></author><author><name sortKey="Coleman, C M" uniqKey="Coleman C">C.M. Coleman</name></author><author><name sortKey="Hart, B J" uniqKey="Hart B">B.J. Hart</name></author><author><name sortKey="Venkataraman, T" uniqKey="Venkataraman T">T. Venkataraman</name></author><author><name sortKey="Holbrook, M R" uniqKey="Holbrook M">M.R. Holbrook</name></author><author><name sortKey="Kindrachuk, J" uniqKey="Kindrachuk J">J. Kindrachuk</name></author><author><name sortKey="Johnson, R F" uniqKey="Johnson R">R.F. Johnson</name></author><author><name sortKey="Olinger, G G" uniqKey="Olinger G">G.G. Olinger</name></author><author><name sortKey="Jahrling, P B" uniqKey="Jahrling P">P.B. Jahrling</name></author><author><name sortKey="Laidlaw, M" uniqKey="Laidlaw M">M. Laidlaw</name></author><author><name sortKey="Johansen, L M" uniqKey="Johansen L">L.M. Johansen</name></author><author><name sortKey="Lear Rooney, C M" uniqKey="Lear Rooney C">C.M. Lear-Rooney</name></author><author><name sortKey="Glass, P J" uniqKey="Glass P">P.J. Glass</name></author><author><name sortKey="Hensley, L E" uniqKey="Hensley L">L.E. Hensley</name></author><author><name sortKey="Frieman, M B" uniqKey="Frieman M">M.B. Frieman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, K" uniqKey="Fan K">K. Fan</name></author><author><name sortKey="Wei, P" uniqKey="Wei P">P. Wei</name></author><author><name sortKey="Feng, Q" uniqKey="Feng Q">Q. Feng</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Ma, L" uniqKey="Ma L">L. Ma</name></author><author><name sortKey="Lai, B" uniqKey="Lai B">B. Lai</name></author><author><name sortKey="Pei, J" uniqKey="Pei J">J. Pei</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Lai, L" uniqKey="Lai L">L. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Xi, K" uniqKey="Xi K">K. Xi</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Santarsiero, B D" uniqKey="Santarsiero B">B.D. Santarsiero</name></author><author><name sortKey="Fu, W" uniqKey="Fu W">W. Fu</name></author><author><name sortKey="Harcourt, B H" uniqKey="Harcourt B">B.H. Harcourt</name></author><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Johnson, M E" uniqKey="Johnson M">M.E. Johnson</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, M F" uniqKey="Hsu M">M.F. Hsu</name></author><author><name sortKey="Kuo, C J" uniqKey="Kuo C">C.J. Kuo</name></author><author><name sortKey="Chang, K T" uniqKey="Chang K">K.T. Chang</name></author><author><name sortKey="Chang, H C" uniqKey="Chang H">H.C. Chang</name></author><author><name sortKey="Chou, C C" uniqKey="Chou C">C.C. Chou</name></author><author><name sortKey="Ko, T P" uniqKey="Ko T">T.P. Ko</name></author><author><name sortKey="Shr, H L" uniqKey="Shr H">H.L. Shr</name></author><author><name sortKey="Chang, G G" uniqKey="Chang G">G.G. Chang</name></author><author><name sortKey="Wang, A H J" uniqKey="Wang A">A.H.J. Wang</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, B L" uniqKey="Ho B">B.L. Ho</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Shi, L" uniqKey="Shi L">L. Shi</name></author><author><name sortKey="Wang, T Y" uniqKey="Wang T">T.Y. Wang</name></author><author><name sortKey="Ho, K I" uniqKey="Ho K">K.I. Ho</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jetsadawisut, W" uniqKey="Jetsadawisut W">W. Jetsadawisut</name></author><author><name sortKey="Nutho, B" uniqKey="Nutho B">B. Nutho</name></author><author><name sortKey="Meeprasert, A" uniqKey="Meeprasert A">A. Meeprasert</name></author><author><name sortKey="Rungrotmongkol, T" uniqKey="Rungrotmongkol T">T. Rungrotmongkol</name></author><author><name sortKey="Kungwan, N" uniqKey="Kungwan N">N. Kungwan</name></author><author><name sortKey="Wolschann, P" uniqKey="Wolschann P">P. Wolschann</name></author><author><name sortKey="Hannongbua, S" uniqKey="Hannongbua S">S. Hannongbua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A. Kilianski</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author><author><name sortKey="Shivanna, V" uniqKey="Shivanna V">V. Shivanna</name></author><author><name sortKey="Narayanan, S" uniqKey="Narayanan S">S. Narayanan</name></author><author><name sortKey="Prior, A M" uniqKey="Prior A">A.M. Prior</name></author><author><name sortKey="Weerasekara, S" uniqKey="Weerasekara S">S. Weerasekara</name></author><author><name sortKey="Hua, D H" uniqKey="Hua D">D.H. Hua</name></author><author><name sortKey="Kankanamalage, A C" uniqKey="Kankanamalage A">A.C. Kankanamalage</name></author><author><name sortKey="Groutas, W C" uniqKey="Groutas W">W.C. Groutas</name></author><author><name sortKey="Chang, K O" uniqKey="Chang K">K.O. Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, V" uniqKey="Kumar V">V. Kumar</name></author><author><name sortKey="Jung, Y S" uniqKey="Jung Y">Y.S. Jung</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, V" uniqKey="Kumar V">V. Kumar</name></author><author><name sortKey="Tan, K P" uniqKey="Tan K">K.P. Tan</name></author><author><name sortKey="Wang, Y M" uniqKey="Wang Y">Y.M. Wang</name></author><author><name sortKey="Lin, S W" uniqKey="Lin S">S.W. Lin</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, C J" uniqKey="Kuo C">C.J. Kuo</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, C J" uniqKey="Kuo C">C.J. Kuo</name></author><author><name sortKey="Chi, Y H" uniqKey="Chi Y">Y.H. Chi</name></author><author><name sortKey="Hsu, J T A" uniqKey="Hsu J">J.T.A. Hsu</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, C J" uniqKey="Kuo C">C.J. Kuo</name></author><author><name sortKey="Shie, J J" uniqKey="Shie J">J.J. Shie</name></author><author><name sortKey="Fang, J M" uniqKey="Fang J">J.M. Fang</name></author><author><name sortKey="Yen, G R" uniqKey="Yen G">G.R. Yen</name></author><author><name sortKey="Hsu, J T A" uniqKey="Hsu J">J.T.A. Hsu</name></author><author><name sortKey="Liu, H G" uniqKey="Liu H">H.G. Liu</name></author><author><name sortKey="Tseng, S N" uniqKey="Tseng S">S.N. Tseng</name></author><author><name sortKey="Chang, S C" uniqKey="Chang S">S.C. Chang</name></author><author><name sortKey="Lee, C Y" uniqKey="Lee C">C.Y. Lee</name></author><author><name sortKey="Shih, S R" uniqKey="Shih S">S.R. Shih</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C C" uniqKey="Lee C">C.C. Lee</name></author><author><name sortKey="Kuo, C J" uniqKey="Kuo C">C.J. Kuo</name></author><author><name sortKey="Ko, T P" uniqKey="Ko T">T.P. Ko</name></author><author><name sortKey="Hsu, M F" uniqKey="Hsu M">M.F. Hsu</name></author><author><name sortKey="Tsui, Y C" uniqKey="Tsui Y">Y.C. Tsui</name></author><author><name sortKey="Chang, S C" uniqKey="Chang S">S.C. Chang</name></author><author><name sortKey="Yang, S" uniqKey="Yang S">S. Yang</name></author><author><name sortKey="Chen, S J" uniqKey="Chen S">S.J. Chen</name></author><author><name sortKey="Chen, H C" uniqKey="Chen H">H.C. Chen</name></author><author><name sortKey="Hsu, M C" uniqKey="Hsu M">M.C. Hsu</name></author><author><name sortKey="Shih, S R" uniqKey="Shih S">S.R. Shih</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author><author><name sortKey="Wang, A H" uniqKey="Wang A">A.H. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, D A" uniqKey="Matthews D">D.A. Matthews</name></author><author><name sortKey="Dragovich, P S" uniqKey="Dragovich P">P.S. Dragovich</name></author><author><name sortKey="Webber, S E" uniqKey="Webber S">S.E. Webber</name></author><author><name sortKey="Fuhrman, S A" uniqKey="Fuhrman S">S.A. Fuhrman</name></author><author><name sortKey="Patick, A K" uniqKey="Patick A">A.K. Patick</name></author><author><name sortKey="Zalman, L S" uniqKey="Zalman L">L.S. Zalman</name></author><author><name sortKey="Hendrickson, T F" uniqKey="Hendrickson T">T.F. Hendrickson</name></author><author><name sortKey="Love, R A" uniqKey="Love R">R.A. Love</name></author><author><name sortKey="Prins, T J" uniqKey="Prins T">T.J. Prins</name></author><author><name sortKey="Marakovits, J T" uniqKey="Marakovits J">J.T. Marakovits</name></author><author><name sortKey="Zhou, R" uniqKey="Zhou R">R. Zhou</name></author><author><name sortKey="Tikhe, J" uniqKey="Tikhe J">J. Tikhe</name></author><author><name sortKey="Ford, C E" uniqKey="Ford C">C.E. Ford</name></author><author><name sortKey="Meador, J W" uniqKey="Meador J">J.W. Meador</name></author><author><name sortKey="Ferre, R A" uniqKey="Ferre R">R.A. Ferre</name></author><author><name sortKey="Brown, E L" uniqKey="Brown E">E.L. Brown</name></author><author><name sortKey="Binford, S L" uniqKey="Binford S">S.L. Binford</name></author><author><name sortKey="Brothers, M A" uniqKey="Brothers M">M.A. Brothers</name></author><author><name sortKey="Delisle, D M" uniqKey="Delisle D">D.M. DeLisle</name></author><author><name sortKey="Worland, S T" uniqKey="Worland S">S.T. Worland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Needle, D" uniqKey="Needle D">D. Needle</name></author><author><name sortKey="Lountos, G T" uniqKey="Lountos G">G.T. Lountos</name></author><author><name sortKey="Waugh, D S" uniqKey="Waugh D">D.S. Waugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pillaiyar, T" uniqKey="Pillaiyar T">T. Pillaiyar</name></author><author><name sortKey="Manickam, M" uniqKey="Manickam M">M. Manickam</name></author><author><name sortKey="Namasivayam, V" uniqKey="Namasivayam V">V. Namasivayam</name></author><author><name sortKey="Hayashi, Y" uniqKey="Hayashi Y">Y. Hayashi</name></author><author><name sortKey="Jung, S H" uniqKey="Jung S">S.H. Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramajayam, R" uniqKey="Ramajayam R">R. Ramajayam</name></author><author><name sortKey="Tan, K P" uniqKey="Tan K">K.P. Tan</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author><author><name sortKey="Oberste, M S" uniqKey="Oberste M">M.S. Oberste</name></author><author><name sortKey="Monroe, S S" uniqKey="Monroe S">S.S. Monroe</name></author><author><name sortKey="Nix, W A" uniqKey="Nix W">W.A. Nix</name></author><author><name sortKey="Campagnoli, R" uniqKey="Campagnoli R">R. Campagnoli</name></author><author><name sortKey="Icenogle, J P" uniqKey="Icenogle J">J.P. Icenogle</name></author><author><name sortKey="Penaranda, S" uniqKey="Penaranda S">S. Penaranda</name></author><author><name sortKey="Bankamp, B" uniqKey="Bankamp B">B. Bankamp</name></author><author><name sortKey="Maher, K" uniqKey="Maher K">K. Maher</name></author><author><name sortKey="Chen, M H" uniqKey="Chen M">M.H. Chen</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S. Tong</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name></author><author><name sortKey="Lowe, L" uniqKey="Lowe L">L. Lowe</name></author><author><name sortKey="Frace, M" uniqKey="Frace M">M. Frace</name></author><author><name sortKey="Derisi, J L" uniqKey="Derisi J">J.L. DeRisi</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Erdman, D D" uniqKey="Erdman D">D.D. Erdman</name></author><author><name sortKey="Peret, T C" uniqKey="Peret T">T.C. Peret</name></author><author><name sortKey="Burns, C" uniqKey="Burns C">C. Burns</name></author><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name></author><author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A. Sanchez</name></author><author><name sortKey="Liffick, S" uniqKey="Liffick S">S. Liffick</name></author><author><name sortKey="Holloway, B" uniqKey="Holloway B">B. Holloway</name></author><author><name sortKey="Limor, J" uniqKey="Limor J">J. Limor</name></author><author><name sortKey="Mccaustland, K" uniqKey="Mccaustland K">K. McCaustland</name></author><author><name sortKey="Olsen Rasmussen, M" uniqKey="Olsen Rasmussen M">M. Olsen-Rasmussen</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R. Fouchier</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Pallansch, M A" uniqKey="Pallansch M">M.A. Pallansch</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shie, J J" uniqKey="Shie J">J.J. Shie</name></author><author><name sortKey="Fang, J M" uniqKey="Fang J">J.M. Fang</name></author><author><name sortKey="Kuo, T H" uniqKey="Kuo T">T.H. Kuo</name></author><author><name sortKey="Kuo, C J" uniqKey="Kuo C">C.J. Kuo</name></author><author><name sortKey="Liang, P H" uniqKey="Liang P">P.H. Liang</name></author><author><name sortKey="Huang, H J" uniqKey="Huang H">H.J. Huang</name></author><author><name sortKey="Wu, Y T" uniqKey="Wu Y">Y.T. Wu</name></author><author><name sortKey="Jan, J T" uniqKey="Jan J">J.T. Jan</name></author><author><name sortKey="Cheng, Y S" uniqKey="Cheng Y">Y.S. Cheng</name></author><author><name sortKey="Wong, C H" uniqKey="Wong C">C.H. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="St John, S E" uniqKey="St John S">S.E. St John</name></author><author><name sortKey="Tomar, S" uniqKey="Tomar S">S. Tomar</name></author><author><name sortKey="Stauffer, S R" uniqKey="Stauffer S">S.R. Stauffer</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thanigaimalai, P" uniqKey="Thanigaimalai P">P. Thanigaimalai</name></author><author><name sortKey="Konno, S" uniqKey="Konno S">S. Konno</name></author><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T. Yamamoto</name></author><author><name sortKey="Koiwai, Y" uniqKey="Koiwai Y">Y. Koiwai</name></author><author><name sortKey="Taguchi, A" uniqKey="Taguchi A">A. Taguchi</name></author><author><name sortKey="Takayama, K" uniqKey="Takayama K">K. Takayama</name></author><author><name sortKey="Yakushiji, F" uniqKey="Yakushiji F">F. Yakushiji</name></author><author><name sortKey="Akaji, K" uniqKey="Akaji K">K. Akaji</name></author><author><name sortKey="Chen, S E" uniqKey="Chen S">S.E. Chen</name></author><author><name sortKey="Naser Tavakolian, A" uniqKey="Naser Tavakolian A">A. Naser-Tavakolian</name></author><author><name sortKey="Schon, A" uniqKey="Schon A">A. Schon</name></author><author><name sortKey="Freire, E" uniqKey="Freire E">E. Freire</name></author><author><name sortKey="Hayashi, Y" uniqKey="Hayashi Y">Y. Hayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Herold, J" uniqKey="Herold J">J. Herold</name></author><author><name sortKey="Schelle, B" uniqKey="Schelle B">B. Schelle</name></author><author><name sortKey="Siddell, S G" uniqKey="Siddell S">S.G. Siddell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Ivanov, K A" uniqKey="Ivanov K">K.A. Ivanov</name></author><author><name sortKey="Putics, A" uniqKey="Putics A">A. Putics</name></author><author><name sortKey="Hertzig, T" uniqKey="Hertzig T">T. Hertzig</name></author><author><name sortKey="Schelle, B" uniqKey="Schelle B">B. Schelle</name></author><author><name sortKey="Bayer, S" uniqKey="Bayer S">S. Bayer</name></author><author><name sortKey="Weissbrich, B" uniqKey="Weissbrich B">B. Weissbrich</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomar, S" uniqKey="Tomar S">S. Tomar</name></author><author><name sortKey="Johnston, M L" uniqKey="Johnston M">M.L. Johnston</name></author><author><name sortKey="St John, S E" uniqKey="St John S">S.E. St John</name></author><author><name sortKey="Osswald, H L" uniqKey="Osswald H">H.L. Osswald</name></author><author><name sortKey="Nyalapatla, P R" uniqKey="Nyalapatla P">P.R. Nyalapatla</name></author><author><name sortKey="Paul, L N" uniqKey="Paul L">L.N. Paul</name></author><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Denison, M R" uniqKey="Denison M">M.R. Denison</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, T R" uniqKey="Tong T">T.R. Tong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tyrrell, D A" uniqKey="Tyrrell D">D.A. Tyrrell</name></author><author><name sortKey="Bynoe, M L" uniqKey="Bynoe M">M.L. Bynoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webber, S E" uniqKey="Webber S">S.E. Webber</name></author><author><name sortKey="Okano, K" uniqKey="Okano K">K. Okano</name></author><author><name sortKey="Little, T L" uniqKey="Little T">T.L. Little</name></author><author><name sortKey="Reich, S H" uniqKey="Reich S">S.H. Reich</name></author><author><name sortKey="Xin, Y" uniqKey="Xin Y">Y. Xin</name></author><author><name sortKey="Fuhrman, S A" uniqKey="Fuhrman S">S.A. Fuhrman</name></author><author><name sortKey="Matthews, D A" uniqKey="Matthews D">D.A. Matthews</name></author><author><name sortKey="Love, R A" uniqKey="Love R">R.A. Love</name></author><author><name sortKey="Hendrickson, T F" uniqKey="Hendrickson T">T.F. Hendrickson</name></author><author><name sortKey="Patick, A K" uniqKey="Patick A">A.K. Patick</name></author><author><name sortKey="Meador, J W" uniqKey="Meador J">J.W. Meador</name></author><author><name sortKey="Ferre, R A" uniqKey="Ferre R">R.A. Ferre</name></author><author><name sortKey="Brown, E L" uniqKey="Brown E">E.L. Brown</name></author><author><name sortKey="Ford, C E" uniqKey="Ford C">C.E. Ford</name></author><author><name sortKey="Binford, S L" uniqKey="Binford S">S.L. Binford</name></author><author><name sortKey="Worland, S T" uniqKey="Worland S">S.T. Worland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author><author><name sortKey="Yang, M" uniqKey="Yang M">M. Yang</name></author><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Lou, Z" uniqKey="Lou Z">Z. Lou</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z. Zhou</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Mo, L" uniqKey="Mo L">L. Mo</name></author><author><name sortKey="Ye, S" uniqKey="Ye S">S. Ye</name></author><author><name sortKey="Pang, H" uniqKey="Pang H">H. Pang</name></author><author><name sortKey="Gao, G F" uniqKey="Gao G">G.F. Gao</name></author><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author><author><name sortKey="Bartlam, M" uniqKey="Bartlam M">M. Bartlam</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author><author><name sortKey="Rao, Z" uniqKey="Rao Z">Z. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, S" uniqKey="Yang S">S. Yang</name></author><author><name sortKey="Chen, S J" uniqKey="Chen S">S.J. Chen</name></author><author><name sortKey="Hsu, M F" uniqKey="Hsu M">M.F. Hsu</name></author><author><name sortKey="Wu, J D" uniqKey="Wu J">J.D. Wu</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author><author><name sortKey="Liu, Y F" uniqKey="Liu Y">Y.F. Liu</name></author><author><name sortKey="Chen, H C" uniqKey="Chen H">H.C. Chen</name></author><author><name sortKey="Kuo, C W" uniqKey="Kuo C">C.W. Kuo</name></author><author><name sortKey="Wu, C S" uniqKey="Wu C">C.S. Wu</name></author><author><name sortKey="Chang, L W" uniqKey="Chang L">L.W. Chang</name></author><author><name sortKey="Chen, W C" uniqKey="Chen W">W.C. Chen</name></author><author><name sortKey="Liao, S Y" uniqKey="Liao S">S.Y. Liao</name></author><author><name sortKey="Chang, T Y" uniqKey="Chang T">T.Y. Chang</name></author><author><name sortKey="Hung, H H" uniqKey="Hung H">H.H. Hung</name></author><author><name sortKey="Shr, H L" uniqKey="Shr H">H.L. Shr</name></author><author><name sortKey="Liu, C Y" uniqKey="Liu C">C.Y. Liu</name></author><author><name sortKey="Huang, Y A" uniqKey="Huang Y">Y.A. Huang</name></author><author><name sortKey="Chang, L Y" uniqKey="Chang L">L.Y. Chang</name></author><author><name sortKey="Hsu, J C" uniqKey="Hsu J">J.C. Hsu</name></author><author><name sortKey="Peters, C J" uniqKey="Peters C">C.J. Peters</name></author><author><name sortKey="Wang, A H" uniqKey="Wang A">A.H. Wang</name></author><author><name sortKey="Hsu, M C" uniqKey="Hsu M">M.C. Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q. Zhao</name></author><author><name sortKey="Weber, E" uniqKey="Weber E">E. Weber</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, L" uniqKey="Zhu L">L. Zhu</name></author><author><name sortKey="George, S" uniqKey="George S">S. George</name></author><author><name sortKey="Schmidt, M F" uniqKey="Schmidt M">M.F. Schmidt</name></author><author><name sortKey="Al Gharabli, S I" uniqKey="Al Gharabli S">S.I. Al-Gharabli</name></author><author><name sortKey="Rademann, J" uniqKey="Rademann J">J. Rademann</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Kumar, Vathan" sort="Kumar, Vathan" uniqKey="Kumar V" first="Vathan" last="Kumar">Vathan Kumar</name></noRegion><name sortKey="Huang, Kai Fa" sort="Huang, Kai Fa" uniqKey="Huang K" first="Kai-Fa" last="Huang">Kai-Fa Huang</name><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name></country><country name="Corée du Sud"><noRegion><name sortKey="Shin, Jin Soo" sort="Shin, Jin Soo" uniqKey="Shin J" first="Jin Soo" last="Shin">Jin Soo Shin</name></noRegion><name sortKey="Go, Yun Young" sort="Go, Yun Young" uniqKey="Go Y" first="Yun Young" last="Go">Yun Young Go</name><name sortKey="Kim, Chonsaeng" sort="Kim, Chonsaeng" uniqKey="Kim C" first="Chonsaeng" last="Kim">Chonsaeng Kim</name><name sortKey="Kim, Meehyein" sort="Kim, Meehyein" uniqKey="Kim M" first="Meehyein" last="Kim">Meehyein Kim</name><name sortKey="Ku, Keun Bon" sort="Ku, Keun Bon" uniqKey="Ku K" first="Keun Bon" last="Ku">Keun Bon Ku</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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